Determining the API crystal form in original/reference preparations and homemade preparations is a key step in the development of generic drugs. Crystal form detection has a series of optional analysis methods, such as X-ray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, vibrational spectroscopy (far-infrared spectroscopy, infrared spectroscopy and Raman spectroscopy), etc. Among them, Raman spectroscopy is fast in analysis and has fingerprint properties for drugs, so it can be used in molecular structure research. Therefore, it is widely used in the quality control of pharmaceutical excipients and on-site rapid inspection.
